Neuronal changes in normal human aging and Alzheimer's disease

被引：192

作者：

Uylings, HBM

de Brabander, JM

机构：

[1] Royal Netherlands Acad Arts & Sci, Netherlands Inst Brain Res, NL-1105 AZ Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Fac Med, Dept Anat, Amsterdam, Netherlands

来源：

BRAIN AND COGNITION | 2002年 / 49卷 / 03期

关键词：

aging; Alzheimer's disease; brain weight; total number of neurons; dendrites; synaptic density; prefrontal cortex; hippocampus;

D O I：

10.1006/brcg.2001.1500

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine. and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to he specific to brain region and cortical layer rather than general feature. In addition. we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared. (C) 2002 Elsevier Science (USA).

引用

页码：268 / 276

页数：9

共 44 条

[1]

BertoniFreddari C, 1996, ANAL QUANT CYTOL, V18, P209

[2] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[3] ORGANIZATION OF THE CEREBRAL CORTEX .3. A STUDY OF AGING IN THE HUMAN CEREBRAL CORTEX [J].

BRODY, H .

JOURNAL OF COMPARATIVE NEUROLOGY, 1955, 102 (02) :511-556

[4] GOLGI-COX AND RAPID GOLGI METHODS AS APPLIED TO AUTOPSIED HUMAN-BRAIN TISSUE - WIDELY DISPARATE RESULTS [J].

BUELL, SJ .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1982, 41 (05) :500-507

[5] QUANTITATIVE EVIDENCE FOR SELECTIVE DENDRITIC GROWTH IN NORMAL HUMAN AGING BUT NOT IN SENILE DEMENTIA [J].

BUELL, SJ ;

COLEMAN, PD .

BRAIN RESEARCH, 1981, 214 (01) :23-41

[6] DIFFERENTIAL SYNAPTIC LOSS IN THE CORTEX IN ALZHEIMERS-DISEASE - A STUDY USING ARCHIVAL MATERIAL [J].

CLINTON, J ;

BLACKMAN, SEA ;

ROYSTON, MC ;

ROBERTS, GW .

NEUROREPORT, 1994, 5 (04) :497-500

[7]

de Brabander JM, 1998, EUR J NEUROSCI, V10, P1261

[8] CHANGES IN BRAIN WEIGHTS DURING SPAN OF HUMAN LIFE - RELATION OF BRAIN WEIGHTS TO BODY HEIGHTS AND BODY WEIGHTS [J].

DEKABAN, AS ;

SADOWSKY, D .

ANNALS OF NEUROLOGY, 1978, 4 (04) :345-356

[9] MORPHOMETRIC AND DENDRITIC ANALYSIS OF FASCIA-DENTATA GRANULE CELLS IN HUMAN AGING AND SENILE DEMENTIA [J].

DERUITER, JP ;

UYLINGS, HBM .

BRAIN RESEARCH, 1987, 402 (02) :217-229

[10] DENDRITIC EXTENT IN HUMAN CA2-3 HIPPOCAMPAL PYRAMIDAL NEURONS IN NORMAL AGING AND SENILE DEMENTIA [J].

FLOOD, DG ;

GUARNACCIA, M ;

COLEMAN, PD .

BRAIN RESEARCH, 1987, 409 (01) :88-96

← 1 2 3 4 5 →