Genomics and proteomics tools for compound mode-of-action studies in drug discovery

被引：12

作者：

Kley, N

Ivanov, I

Meier-Ewert, S

机构：

[1] GPC Bitoech Inc, Waltham, MA 02451 USA

[2] GPC Biotech AG, D-82152 Martinsried, Germany

来源：

PHARMACOGENOMICS | 2004年 / 5卷 / 04期

关键词：

chemical biology; chemical genetics; gene expression; molecular interaction; mode of action; pharmacogenomics; pharmacoproteomics; small molecule drugs;

D O I：

10.1517/14622416.5.4.395

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A broad range of genomics and proteomics technologies are increasingly being integrated into emerging research fields such as pharmacogenomics, pharmacoproteomics, chemogenomics, chemical genetics, and chemical biology. Here we review applications of genomic and proteomic technologies to drug mechanism-of-action studies and how these are beginning to impact the drug discovery process.

引用

页码：395 / 404

页数：10

共 83 条

[1] Chemical strategies for functional proteomics [J].

Adam, GC ;

Sorensen, EJ ;

Cravatt, BF .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (10) :781-790

[2] Mass spectrometry-based proteomics [J].

Aebersold, R ;

Mann, M .

NATURE, 2003, 422 (6928) :198-207

[3] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[4] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J].

Alon, U ;

Barkai, N ;

Notterman, DA ;

Gish, K ;

Ybarra, S ;

Mack, D ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6745-6750

[5] A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors [J].

Becker, F ;

Murthi, K ;

Smith, C ;

Come, J ;

Costa-Roldán, N ;

Kaufmann, C ;

Hanke, U ;

Degenhart, C ;

Baumann, S ;

Wallner, W ;

Huber, A ;

Dedier, S ;

Dill, S ;

Kinsman, D ;

Hediger, M ;

Bockovich, N ;

Meier-Ewert, S ;

Kluge, AF ;

Kley', N .

CHEMISTRY & BIOLOGY, 2004, 11 (02) :211-223

[6] Pharmacogenomic analysis: Correlating molecular substructure classes with microarray gene expression data [J].

Blower P.E. ;

Yang C. ;

Fligner M.A. ;

Verducci J.S. ;

Yu L. ;

Richman S. ;

Weinstein J.N. .

The Pharmacogenomics Journal, 2002, 2 (4) :259-271

[7] Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme [J].

Borodovsky, A ;

Ovaa, H ;

Kolli, N ;

Gan-Erdene, T ;

Wilkinson, KD ;

Ploegh, HL ;

Kessler, BM .

CHEMISTRY & BIOLOGY, 2002, 9 (10) :1149-1159

[8] The use and analysis of microarray data [J].

Butte, A .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (12) :951-960

[9] Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks [J].

Butte, AJ ;

Tamayo, P ;

Slonim, D ;

Golub, TR ;

Kohane, IS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12182-12186

[10] Model systems in drug discovery: chemical genetics meets genomics [J].

Carroll, PM ;

Dougherty, B ;

Ross-Macdonald, P ;

Browman, K ;

FitzGerald, K .

PHARMACOLOGY & THERAPEUTICS, 2003, 99 (02) :183-220

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