Effects of sympathetic nerve blockade on vasoconstrictive properties of nitric oxide synthase inhibition in sheep

被引：6

作者：

Booke, M ^{[1
]}

Waurick, R ^{[1
]}

VanAken, H ^{[1
]}

Bone, HG ^{[1
]}

Meissner, A ^{[1
]}

Prien, T ^{[1
]}

Meyer, J ^{[1
]}

机构：

[1] UNIV MUNSTER, DEPT ANESTHESIOL & INTENS CARE MED, D-48129 MUNSTER, GERMANY

来源：

CARDIOVASCULAR RESEARCH | 1997年 / 36卷 / 01期

关键词：

nitric oxide synthase inhibition; epidural anesthesia; sympathetic nerve activity; hemodynamics; sheep;

D O I：

10.1016/S0008-6363(97)00145-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Inhibition of nitric oxide synthase causes intense vasoconstriction. This effect is thought to be dependent on sympathetic nerve activity. Thus. we investigated the vasoconstrictive effects sf the nitric oxide synthase inhibitor N-G-nitro-L-arginine methyl ester (L-NAME) in sheep, in which a reversible sympathetic block was established by thoracic epidural anesthesia. Methods: Sheep (n = 11) were surgically prepared for chronic study. After at least 5 days of recovery, L-NAME was continuously administered and hemodynamics were monitored. This was done in sheep with and without sympathetic blockade in randomized order. Results: The vasoconstrictive effects of L-NAME were similar in sheep with and without sympathetic blockade. Conclusion: The obtained results suggest that the vasoconstrictive properties of nitric oxide synthase inhibitors are independent of sympathetic tone. (C) 1997 Elsevier Science B.V.

引用

页码：111 / 117

页数：7

共 50 条

[1] INTERACTIONS OF NITRIC-OXIDE SYNTHASE INHIBITORS AND DEXAMETHASONE WITH ALPHA-ADRENOCEPTOR-MEDIATED RESPONSES IN RAT AORTA [J].

ADEAGBO, ASO ;

TRIGGLE, CR .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 109 (02) :495-501

[2]

ALTURA BM, 1980, FED PROC, V39, P1584

[3] TONE DEPENDENT NITRIC-OXIDE PRODUCTION IN OVINE VESSELS IN-VITRO [J].

BANSAL, V ;

TOGA, H ;

RAJ, JU .

RESPIRATION PHYSIOLOGY, 1993, 93 (02) :249-260

[4] S-ETHYLISOTHIOUREA, A NONAMINO ACID INHIBITOR OF NITRIC-OXIDE SYNTHASE, REVERSES SEPTIC VASODILATION IN SHEEP [J].

BOOKE, M ;

HINDER, F ;

TRABER, LD ;

MCGUIRE, R ;

TRABER, DL .

SHOCK, 1995, 4 (04) :274-281

[5]

Booke M, 1995, New Horiz, V3, P123

[6] Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep [J].

Booke, M ;

Hinder, F ;

McGuire, R ;

Traber, LD ;

Traber, DL .

CRITICAL CARE MEDICINE, 1996, 24 (05) :835-844

[7] The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep [J].

Booke, M ;

Armstrong, C ;

Hinder, F ;

Conroy, B ;

Traber, LD ;

Traber, DL .

ANESTHESIA AND ANALGESIA, 1996, 82 (04) :738-743

[8]

BOOKE M, 1995, ROLE NITRIC OXIDE SE, P217

[9] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].

BREDT, DS ;

HWANG, PM ;

SNYDER, SH .

NATURE, 1990, 347 (6295) :768-770

[10] THE CENTRAL EFFECTS OF A NITRIC-OXIDE SYNTHASE INHIBITOR (N-OMEGA-NITRO-L-ARGININE) ON BLOOD-PRESSURE AND PLASMA-RENIN [J].

ELKARIB, AO ;

SHENG, JJ ;

BETZ, AL ;

MALVIN, RL .

CLINICAL AND EXPERIMENTAL HYPERTENSION, 1993, 15 (05) :819-832

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