EP1572:: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

被引：41

作者：

Broglio, F

Boutignon, F

Benso, A

Gottero, C

Prodam, F

Arvat, E

Ghè, C

Catapano, F

Torsello, A

Locatelli, V

Muccioli, G

Boeglin, D

Guerlavais, V

Frehrentz, JA

Martinez, J

Ghigo, E

Deghenghi, R

机构：

[1] Univ Turin, Dept Internal Med, Div Endocrinol, I-10126 Turin, Italy

[2] Univ Turin, Dept Anat Pharmacol & Forens Med, I-10126 Turin, Italy

[3] Univ Milano Bicocca, Dept Expt & Environm Med & Biotechnol, Milan, Italy

[4] Europeptides, Argenteuil, France

[5] Univ Montpellier, Lab Aminoacides Peptides & Prot, Montpellier, France

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2002年 / 25卷 / 08期

关键词：

synthetic GH secretagogues; GH; ghrelin receptors; oral administration; humans;

D O I：

10.1007/BF03345096

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagrogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 mug/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP 1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

引用

页码：RC26 / RC28

页数：3

共 9 条

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