TSC1-TSC2: a complex tale of PKB-mediated S6K regulation

被引：130

作者：

McManus, EJ ^{[1
]}

Alessi, DR ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1038/ncb0902-e214

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin- and growth factor-stimulated protein kinases protein kinase B (PKB)/Akt and p70 S6 ribosomal kinase (S6K) are crucial regulators of cell growth. Recent advances, supported by work in this issue of Nature Cell Biology, have indicated that the tumour suppressor tuberous sclerosis complex-2 (TSC2) functions as an antagonist of S6K activation, an inhibition that is relieved by PKB-mediated phosphorylation of TSC2. In contrast to some previous models, these findings indicate that PKB functions upstream of S6K.

引用

页码：E214 / E216

页数：3

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