Reaction of α-amidoalkylphenyl sulfones with Reformatsky reagents.: A new entry to β-amino esters

被引：28

作者：

Mecozzi, T ^{[1
]}

Petrini, M ^{[1
]}

机构：

[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 15期

关键词：

amino acids and derivatives; N-imides; Reformatsky reagents; sulfones;

D O I：

10.1016/S0040-4039(00)00245-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of Reformatsky reagents with alpha-amidoalkylphenyl sulfones proceeds in dichloromethane at room temperature leading to the synthesis of the corresponding beta-amino esters in good yields. The procedure presents syn stereoselectivity and can be also extended to Reformatsky reagents based on gamma-bromocrotonates. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2709 / 2712

页数：4

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