Protein aggregation in crowded environments

被引：300

作者：

Ellis, R. John ^{[1
]}

Minton, Allen P.

机构：

[1] Univ Warwick, Dept Sci Biol, Coventry CV4 7AL, W Midlands, England

[2] NIDDK, Lab Biochem Pharmacol, NIH, Bethesda, MD 20892 USA

来源：

BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 05期

关键词：

excluded volume; macromolecular crowding; molecular chaperones; protein aggregation; protein folding;

D O I：

10.1515/BC.2006.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The generic tendency of proteins to aggregate into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.

引用

页码：485 / 497

页数：13

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