Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

被引：37

作者：

Pendleton, N

Payton, A

van den Boogerd, EH

Holland, F

Diggle, P

Rabbitt, PMA

Horan, MA

Worthington, J

Ollier, WER

机构：

[1] Univ Manchester, Hope Hosp, Clin Gerontol Grp, Clin Div 1, Salford M6 8HD, Lancs, England

[2] Univ Manchester, Ctr Integrated Genom Med Res, Manchester M13 9PT, Lancs, England

[3] GlaxoSmithKline, NFSPS, Harlow CM19 5AW, Essex, England

[4] Univ Lancaster, Dept Math & Stat, Lancaster LA1 4YW, England

[5] Univ Manchester, Age & Cognit Performance Res Ctr, Manchester M13 9PL, Lancs, England

[6] Univ Manchester, ARC, Epidemiol Res Unit, Manchester M13 9PT, Lancs, England

来源：

NEUROSCIENCE LETTERS | 2002年 / 324卷 / 01期

关键词：

apolipoprotein E; intelligence; genetics; aged;

D O I：

10.1016/S0304-3940(02)00135-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P = 0.48 and P = 0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：74 / 76

页数：3

共 12 条

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