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Galactose oxidase and alcohol oxidase: Scope and limitations for the enzymatic synthesis of aldehydes

被引：45
作者：
Siebum, Arjan
van Wijk, Arjan
Schoevaart, Rob
Kieboom, Tom
机构：
[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
[2] CLEA Technol BV, NL-2628 BL Delft, Netherlands
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2006年 / 41卷 / 3-4期
关键词：
reaction cascades; alcohol oxidase; galactose oxidase; biocatalysis; synthesis;
D O I：
10.1016/j.molcatb.2006.04.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The utility of both galactose oxidase and alcohol oxidase for alcohol-to-aldehyde oxidation has been investigated, from a synthetic point of view. The speed of reaction and degree of conversion has been measured for 29 different primary alcohols. The two oxidative enzymes show complementary synthetic use, i.e. galactose oxidase for galactose-derived polyols and alcohol oxidase for aliphatic mono- and diols. Alcohol oxidase has been successfully used in combination with the aldolase DERA in a two-step, one-pot reaction cascade. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：141 / 145
页数：5
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