Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion

被引：156

作者：

de Wilt, JHW

ten Hagen, TLM

de Boeck, G

van Tiel, ST

de Bruijn, EA

Eggermont, AMM

机构：

[1] Univ Hosp Rotterdam Dijkzigt, Daniel den Hoed Canc Ctr, Dept Surg Oncol, NL-3075 EA Rotterdam, Netherlands

[2] Univ Antwerp, Organ Chem Lab, B-2020 Antwerp, Belgium

[3] Katholieke Univ Leuven, Expt Oncol Lab, Louvain, Belgium

来源：

BRITISH JOURNAL OF CANCER | 2000年 / 82卷 / 05期

关键词：

TNF; melphalan; tissue concentration; isolated limb perfusion; rats;

D O I：

10.1054/bjoc.1999.1032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several possible mechanisms for the synergistic anti-tumour effects between tumour necrosis factor alpha (TNF-alpha) and melphalan after isolated limb perfusion (ILP) have been presented. We found a significant sixfold increase in melphalan tumour tissue concentration after ILP when TNF-alpha was added to the perfusate, which provides a straightforward explanation for the observed synergism between melphalan and TNF-alpha in ILP. (C) 2000 Cancer Research Campaign.

引用

页码：1000 / 1003

页数：4

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