Detection and characterization of MuSK antibodies in seronegative myasthenia gravis

被引：316

作者：

McConville, J

Farrugia, ME

Beeson, D

Kishore, U

Metcalfe, R

Newsom-Davis, J

Vincent, A

机构：

[1] So Gen Hosp, Dept Clin Neurol, Glasgow G51 4TF, Lanark, Scotland

[2] Weatherall Inst Mol Med, Oxford, England

[3] Dept Clin Neurol, Oxford, England

来源：

ANNALS OF NEUROLOGY | 2004年 / 55卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1002/ana.20061

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antibodies to rat muscle specific kinase, MUSK, have recently been identified in some generalized "seronegative" myasthenia gravis (SNMG) patients, who are often females with marked bulbar symptoms. Using immunoprecipitation of I-125-labelled-human MUSK, 27 of 66 (41%) seronegative patients were positive, but 18 ocular SNMG patients, 105 AChR antibody positive MG patients, and 108 controls were negative. The antibodies are of high affinity (Kds around 100 pM) with titers between 1 and 200 nM. They bind to the extracellular Ig-like domains of soluble or native MUSK. Surprisingly they are predominantly in the IgG4 subclass. MuSK-antibody associated MG may be differnet in etiological and pathological mechanisms.

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收藏

页码：580 / 584

页数：5

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