Hormone-sensitive prostate cancer: a case of ETS gene fusion heterogeneity

被引：20

作者：

Attard, G. ^{[1
]}

Jameson, C. ^{[1
]}

Moreira, J. ^{[1
]}

Flohr, P. ^{[1
]}

Parker, C. ^{[1
]}

Dearnaley, D. ^{[1
]}

Cooper, C. S. ^{[1
]}

de Bono, J. S. ^{[1
]}

机构：

[1] Inst Canc Res, Royal Marsden NHS Fdn Trust, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5PT, Surrey, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 62卷 / 04期

基金：

英国医学研究理事会;

关键词：

TMPRSS2;

D O I：

10.1136/jcp.2008.061515

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Fusion of the hormone-regulated gene TMPRSS2 with ERG occurs in 50-70% of prostate cancers; fusions of ETV1 with one of several partners occur in approximately 10% of prostate cancers. These two translocations are mutually exclusive. The presence of subclasses of these chromosomal rearrangements may indicate worse prognosis, with the subclass 2+Edel, which has duplication of TMPRSS2: ERG fusion sequences, indicating particularly poor survival. However as this case shows, significant heterogeneity can exist with ERG and ETV1 rearrangements occurring in both prostate intra-epithelial neoplasia and cancer in the same prostatectomy specimen and with adjacent cancer areas containing a single copy, duplication and even triplication of the rearranged locus. As the majority of ETS gene fusions are hormone regulated, they could explain the pathogenesis underlying exquisitely hormone-sensitive prostate cancer. This is exemplified by the case presented here of a patient diagnosed in 1991 who remains asymptomatic and chemotherapy-naive after having long-lasting tumour responses to multiple lines of systemic hormonal treatments.

引用

页码：373 / 376

页数：4

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