Human breast tissue characterisation with small-angle X-ray scattering

被引：23

作者：

Fernández, M

Keyriläinen, J

Karjalainen-Lindsberg, ML

Leidenius, M

von Smitten, K

Fiedler, S

Suortti, P

机构：

[1] Univ Helsinki, Dept Phys Sci, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Cent Hosp, Dept Phys, HUCH Canc Ctr, FIN-00170 Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Dept Pathol, HUCH Lab Diag, FIN-00170 Helsinki, Finland

[4] Univ Helsinki, Cent Hosp, Maria Hosp, Dept Surg, FIN-00029 Helsinki, Finland

[5] European Synchrotron Radiat Facil, F-38043 Grenoble, France

来源：

SPECTROSCOPY-AN INTERNATIONAL JOURNAL | 2004年 / 18卷 / 02期

关键词：

D O I：

10.1155/2004/906243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Small-angle X-ray scattering (SAXS) patterns from breast tissue samples are compared with their histology. Formalin fixed human breast tissue specimens containing ductal and lobular carcinoma were studied. Histo-pathological information is compared with the scattering data, and there is a clear spatial correlation. Supra-molecular organisation of collagen fibrils is modelled and the model is used to create scattering maps. The model parameters include the axial periodicity (d-spacing), radius and packing of the fibrils, and these are derived from comparison with the experimental scattering patterns. The d-spacing is to 0.5% larger in malignant zones of the tumours than in the healthy zones. There are also characteristic differences in the fibril diameter and packing.

引用

页码：167 / 176

页数：10

共 14 条

[1] Comparison between a position sensitive germanium detector and a taper optics CCD "FRELON" camera for diffraction enhanced imaging [J].