Increased antistreptococcal antibody titers and antii-basal ganglia antibodies in patients with Tourette syndrome: Controlled cross-sectional study

被引:44
作者
Rizzo, Renata
Gulisano, Mariangela
Pavone, Piero
Fogliani, Fabia
Robertson, Mary M.
机构
[1] Univ Catania, Dipartimento Pediat, Sect Child Neuropsychiat, I-95125 Catania, Italy
[2] UCL, Dept Mental Hlth Sci, London, England
关键词
D O I
10.1177/08830738060210091001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The association between Tourette syndrome, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder following streptococcal infections has been documented, but with conflicting reports. We thus felt it was important to investigate this association in a group of Italian patients not previously documented. We took blood on 69 patients with Tourette syndrome and 72 age- and sex-matched tic-free controls. Laboratory staff were blind to the diagnostic status of the subjects. Evidence of recent streptococcal infection was defined using antistreptolysin titers. Anti-basal ganglia antibodies were determined using human basal ganglia sections. Statistical analysis was conducted using analysis of variance and chi-square tests. Raised antistreptolysin titers were found in 41 of 69 (59%) patients with Tourette syndrome and 14 of 72 (19%) controls (P = .000). Positive anti-basal ganglia antibodies were found in 22 of 69 (32%) subjects with Tourette syndrome compared with 7 of 72 (10%) controls, which was also significant (P = .002). Raised antistreptolysin titers were detected in 18 of 22 (82%) patients with Tourette syndrome with positive anti-basal ganglia antibodies and 22 of 47 (47%) patients with negative anti-basal ganglia antibodies (P = .01). These results support the reported association between streptococcal infection and anti-basal ganglia antibodies and some patients with Tourette syndrome.
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页码:747 / 753
页数:7
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