Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

被引：572

作者：

Yang, Shengyu ^{[1
]}

Zhang, J. Jillian ^{[1
]}

Huang, Xin-Yun ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Physiol, New York, NY 10065 USA

来源：

CANCER CELL | 2009年 / 15卷 / 02期

关键词：

CAPACITATIVE CALCIUM-ENTRY; CYTOSOLIC-FREE CALCIUM; CHANNEL FUNCTION; CRAC CHANNEL; CA2+ INFLUX; TYROSINE PHOSPHORYLATION; CANCER METASTASIS; INTEGRIN; MODULATION; TURNOVER;

D O I：

10.1016/j.ccr.2008.12.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor metastasis is the primary cause of death of cancer patients. Understanding the molecular mechanisms underlying tumor metastasis will provide potential drug targets. We report here that Orail1 and STIM1, both of which are involved in store-operated calcium entry, are essential for breast tumor cell migration in vitro and tumor metastasis in mice. Reduction of Orai1 or STIM1 by RNA interference in highly metastatic human breast cancer cells or treatment with a pharmacological inhibitor of store-operated calcium channels decreased tumor metastasis in animal models. Our data demonstrate a role for Orai1 and STIM1 in tumor metastasis and suggest store-operated calcium entry channels as potential cancer therapeutic targets.

引用

页码：124 / 134

页数：11

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