Searching for genetic determinants of human aging and longevity: opportunities and challenges

被引：13

作者：

Vijg, J ^{[1
]}

van Orsouw, N ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Sam & Ann Barshop Ctr Longev & Aging Studies, San Antonio, TX 78245 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2002年 / 123卷 / 2-3期

关键词：

aging and longevity genes; single nucleotide polymorphism; direct association studies; BRCA1; two-dimensional gene scanning;

D O I：

10.1016/S0047-6374(01)00346-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One way of testing possible causal relationships between various functional pathways and aging and longevity processes is to comparatively analyze groups of elderly individuals with select phenotypes for sequence variation in all genes participating in these pathways. Such direct association analysis to identify 'candidate pathways' in aging and longevity is theoretically feasible, with the complete sequence of the human genome known and massive gene annotation projects underway, To find all possible sequence variation of a large number of genes in aging populations. efficient genotyping methods are needed. Here, we describe the use of one such method, two-dimensional gene scanning (TDGS), for screening populations of centenarians and controls for polymorphic variation in the large BRCA1 breast cancer susceptibility gene. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：195 / 205

页数：11

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