Rituximab therapy in autoimmune pulmonary alveolar proteinosis

被引：72

作者：

Borie, R. ^{[2
]}

Debray, M-P. ^{[1
]}

Laine, C. ^{[4
]}

Aubier, M. ^{[2
,3
]}

Crestani, B. ^{[2
,3
]}

机构：

[1] Hop Bichat Claude Bernard, AP HP, Serv Radiol, Paris, France

[2] Hop Bichat Claude Bernard, AP HP, Serv Pneumol A, Paris, France

[3] Univ Paris 07, INSERM, U700, Fac Med Denis Diderot, Paris, France

[4] CHU Pontchaillou, Dept Immunol, Rennes, France

来源：

EUROPEAN RESPIRATORY JOURNAL | 2009年 / 33卷 / 06期

关键词：

CD20; crazy paving; granulocyte-macrophage colony-stimulating factor; interstitial pneumonia; pulmonary alveolar proteinosis; COLONY-STIMULATING FACTOR; GM-CSF; RHEUMATOID-ARTHRITIS;

D O I：

10.1183/09031936.00160908

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Idiopathic pulmonary alveolar proteinosis is presumed to be an autoimmune disorder that may lead to pulmonary insufficiency. However, steroids do not appear to be effective and the standard of therapy is whole-lung lavage. We report the first case of successful therapy with rituximab, which addresses the pathogenic mechanism of pulmonary alveolar proteinosis.

引用

页码：1503 / 1506

页数：4

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