Resistance in the environment

被引:662
作者
Kümmerer, K [1 ]
机构
[1] Freiburg Univ Hosp, Inst Environm Med & Hosp Epidemiol, Appl Environm Res Sect, D-79106 Freiburg, Germany
关键词
environmental microbiology; gene transfer; ecotoxicity; xenobiotics;
D O I
10.1093/jac/dkh325
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Antibiotics, disinfectants and bacteria resistant to them have been detected in environmental compartments such as waste water, surface water, ground water, sediments and soils. Antibiotics are released into the environment after their use in medicine, veterinary medicine and their employment as growth promoters in animal husbandry, fish farming and other fields. There is increasing concern about the growing resistance of pathogenic bacteria in the environment, and their ecotoxic effects. Increasingly, antibiotic resistance is seen as an ecological problem. This includes both the ecology of resistance genes and that of the resistant bacteria themselves. Little is known about the effects of subinhibitory concentrations of antibiotics and disinfectants on environmental bacteria, especially with respect to resistance. According to the present state of our knowledge, the impact on the frequency of resistance transfer by antibacterials present in the environment is questionable. The input of resistant bacteria into the environment seems to be an important source of resistance in the environment. The possible impact of resistant bacteria on the environment is not yet known. Further research into these issues is warranted.
引用
收藏
页码:311 / 320
页数:10
相关论文
共 100 条
[1]   Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark [J].
Aarestrup, FM ;
Seyfarth, AM ;
Emborg, HD ;
Pedersen, K ;
Hendriksen, RS ;
Bager, F .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (07) :2054-2059
[2]   Biodegradability of cefotiam, ciprofloxacin, meropenem, penicillin G, and sulfamethoxazole and inhibition of waste water bacteria [J].
Al-Ahmad, A ;
Daschner, FD ;
Kümmerer, K .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1999, 37 (02) :158-163
[3]   Role of Acinetobacter for biodegradability of quaternary ammonium compounds [J].
Al-Ahmad, A ;
Wiedmann-Al-Ahmad, M ;
Schön, G ;
Daschner, FD ;
Kümmerer, K .
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2000, 64 (06) :764-770
[4]  
ALEXAY R, 2001, P 11 ANN M SETAC EUR, P110
[5]   DISTRIBUTION OF TETRACYCLINE RESISTANCE DETERMINANTS AMONG GRAM-NEGATIVE BACTERIA ISOLATED FROM POLLUTED AND UNPOLLUTED MARINE-SEDIMENTS [J].
ANDERSEN, SR ;
SANDAA, RA .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1994, 60 (03) :908-912
[6]  
[Anonymous], ANTIBIOTICS LAB MED
[7]  
[Anonymous], 1998, ANTIMICROBIAL RESIST
[8]   ANTIBIOTIC-RESISTANT BACTERIA IN DRINKING-WATER [J].
ARMSTRONG, JL ;
SHIGENO, DS ;
CALOMIRIS, JJ ;
SEIDLER, RJ .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1981, 42 (02) :277-283
[9]  
BARKAY T, 1995, FEMS MICROBIOL ECOL, V16, P43, DOI 10.1111/j.1574-6941.1995.tb00267.x
[10]   Genetic transformation in freshwater: Escherichia coli is able to develop natural competence [J].
Baur, B ;
Hanselmann, K ;
Schlimme, W ;
Jenni, B .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1996, 62 (10) :3673-3678