Choice of an oral beta-lactam antibiotic for infections due to penicililin-resistant Streptococcus pneumoniae

被引：18

作者：

Goldstein, FW

机构：

[1] Lab. de Microbiologie Med., Fondation Hôpital Saint-Joseph, Paris

[2] Lab. de Microbiologie Med., Fondation Hôpital Saint-Joseph, F-75674 Paris Cedex 14

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 1997年 / 29卷 / 03期

关键词：

D O I：

10.3109/00365549709019038

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity, pharmacokinetic and pharmacodynamic parameters of 5 oral beta-lactams have been compared against 400 penicillin-resistant Streptococcus pneumoniae (PRSP) isolated in 9 European countries. AU the data have been calculated for the highest recommended oral dosage in France. Amoxicillin was by far the most effective antibiotic when considering its intrinsic activity (96% of the PRSP inhibited at 2 mg/l), the inhibitory quotient (100% of the PRSP > 1 vs 69.2% for cefuroxime) or a time above MIC > 40% which best correlates with clinical results (96% for amoxicillin vs < 25% for the cephalosporins).

引用

页码：255 / 257

页数：3

共 19 条

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