Sequence diversity of the haemagglutinin open reading frame of recent highly pathogenic avian influenza H5N1 isolates from Egypt

被引:31
作者
Abdel-Moneim, Ahmed S. [2 ]
Shany, Salama A. S. [3 ]
Fereidouni, Sasan R. [1 ]
Eid, Bahaa T. M. [3 ]
El-Kady, Magdy F. [3 ]
Starick, Elke [1 ]
Harder, Timm [1 ]
Keil, Guenther M. [1 ]
机构
[1] Fed Res Inst Anim Hlth, Friedrich Loeffler Inst, D-17493 Greifswald, Germany
[2] Beni Suef Univ, Dept Virol, Bani Suwayf 62511, Egypt
[3] Beni Suef Univ, Poultry Dept, Fac Vet Med, Bani Suwayf 62511, Egypt
关键词
VIRUSES; DISEASE; BIRDS; MODEL;
D O I
10.1007/s00705-009-0461-2
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The sequences encoding the haemagglutinin (HA) of twelve H5N1 isolates obtained in 2006 and 2007 from different avian species in backyard holdings and poultry farms in Egypt revealed amino acid variations across the polypeptide and also in the polybasic cleavage motif of three of the isolates from backyard poultry with one, so far, unique mutation in an isolate from a chicken. The HAs of two isolates (A/goose/Egypt/R4/2007, A/chicken/Egypt/R3/2007) collected on the same day in the same village from two neighbouring houses were found to differ from each other. Five out of the seven nucleotide exchanges in these two isolates were translationally silent, and two resulted in amino acid substitutions: one in the polybasic cleavage motif and the other in the signal peptide. Circulation of different H5N1 strains possessing considerable variations in backyard poultry, particularly domestic waterfowl, draws attention to the evolution of H5N1 subtypes in Egypt.
引用
收藏
页码:1559 / 1562
页数:4
相关论文
共 15 条
  • [1] Epidemiological Findings of Outbreaks of Disease Caused by Highly Pathogenic H5N1 Avian Influenza Virus in Poultry in Egypt During 2006
    Aly, M. M.
    Arafa, A.
    Hassan, M. K.
    [J]. AVIAN DISEASES, 2008, 52 (02) : 269 - 277
  • [2] Continuing progress towards a unified nomenclature for the highly pathogenic H5N1 avian influenza viruses: divergence of clade 2.2 viruses
    Brown, Ian H.
    Capua, Ilaria
    Cattoli, Giovanni
    Chen, Hualan
    Cox, Nancy
    Davis, C. Todd
    Donis, Ruben O.
    Fouchier, Ron A. M.
    Garten, Rebecca
    Guan, Yi
    Hay, Alan
    Kawaoka, Yoshihiro
    Mackenzie, John
    McCauley, John
    Mumford, Elizabeth
    Olsen, Christopher
    Perdue, Michael L.
    Russell, Colin A.
    Smith, Catherine
    Smith, Derek
    Smith, Gavin J. D.
    Shu, Yuelong
    Tashiro, Masato
    Vijaykrishna, Dhanasekaran
    Webster, Robert
    [J]. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2009, 3 (02) : 59 - 62
  • [3] Rapid pathotyping of recent H5N1 highly pathogenic avian influenza viruses and of H5 viruses with low pathogenicity by RT-PCR and restriction enzyme cleavage pattern (RECP)
    Fereidouni, Sasan R.
    Harder, Timm C.
    Starick, Elke
    [J]. JOURNAL OF VIROLOGICAL METHODS, 2008, 154 (1-2) : 14 - 19
  • [4] Characterization of a novel influenza a virus hemagglutinin subtype (H16) obtained from black-headed gulls
    Fouchier, RAM
    Munster, V
    Wallensten, A
    Bestebroer, TM
    Herfst, S
    Smith, D
    Rimmelzwaan, GF
    Olsen, B
    Osterhaus, ADME
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (05) : 2814 - 2822
  • [5] Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
    Guan, Y
    Peiris, JSM
    Lipatov, AS
    Ellis, TM
    Dyrting, KC
    Krauss, S
    Zhang, LJ
    Webster, RG
    Shortridge, KF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) : 8950 - 8955
  • [6] A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood
    Guindon, S
    Gascuel, O
    [J]. SYSTEMATIC BIOLOGY, 2003, 52 (05) : 696 - 704
  • [7] Bayesian phylogenetic inference from animal mitochondrial genome arrangements
    Larget, B
    Simon, DL
    Kadane, JB
    [J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 2002, 64 : 681 - 693
  • [8] Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
    Li, KS
    Guan, Y
    Wang, J
    Smith, GJD
    Xu, KM
    Duan, L
    Rahardjo, AP
    Puthavathana, P
    Buranathai, C
    Nguyen, TD
    Estoepangestie, ATS
    Chaisingh, A
    Auewarakul, P
    Long, HT
    Hanh, NTH
    Webby, RJ
    Poon, LLM
    Chen, H
    Shortridge, KF
    Yuen, KY
    Webster, RG
    Peiris, JSM
    [J]. NATURE, 2004, 430 (6996) : 209 - 213
  • [9] The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties
    Matrosovich, M
    Zhou, N
    Kawaoka, Y
    Webster, R
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (02) : 1146 - 1155
  • [10] jModelTest: Phylogenetic model averaging
    Posada, David
    [J]. MOLECULAR BIOLOGY AND EVOLUTION, 2008, 25 (07) : 1253 - 1256