The sequences encoding the haemagglutinin (HA) of twelve H5N1 isolates obtained in 2006 and 2007 from different avian species in backyard holdings and poultry farms in Egypt revealed amino acid variations across the polypeptide and also in the polybasic cleavage motif of three of the isolates from backyard poultry with one, so far, unique mutation in an isolate from a chicken. The HAs of two isolates (A/goose/Egypt/R4/2007, A/chicken/Egypt/R3/2007) collected on the same day in the same village from two neighbouring houses were found to differ from each other. Five out of the seven nucleotide exchanges in these two isolates were translationally silent, and two resulted in amino acid substitutions: one in the polybasic cleavage motif and the other in the signal peptide. Circulation of different H5N1 strains possessing considerable variations in backyard poultry, particularly domestic waterfowl, draws attention to the evolution of H5N1 subtypes in Egypt.
机构:
Vet Labs Agcy, Addlestone, Surrey, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Brown, Ian H.
Capua, Ilaria
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Inst Zooprofilatt Sperimentale Venezie, Padua, ItalyCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Capua, Ilaria
Cattoli, Giovanni
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Inst Zooprofilatt Sperimentale Venezie, Padua, ItalyCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Cattoli, Giovanni
Chen, Hualan
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机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Chen, Hualan
Cox, Nancy
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机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Cox, Nancy
Davis, C. Todd
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h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Davis, C. Todd
Donis, Ruben O.
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Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Donis, Ruben O.
Fouchier, Ron A. M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, NL-3000 DR Rotterdam, NetherlandsCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Fouchier, Ron A. M.
Garten, Rebecca
论文数: 0引用数: 0
h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Garten, Rebecca
Guan, Yi
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h-index: 0
机构:
Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Guan, Yi
Hay, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Med Res, MRC, London NW7 1AA, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Hay, Alan
Kawaoka, Yoshihiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Madison, WI USA
Univ Tokyo, Inst Med Sci, Tokyo, JapanCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Kawaoka, Yoshihiro
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Mackenzie, John
McCauley, John
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h-index: 0
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Natl Inst Med Res, MRC, London NW7 1AA, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
McCauley, John
Mumford, Elizabeth
论文数: 0引用数: 0
h-index: 0
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WHO, GIP, EPR, Geneva, SwitzerlandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Mumford, Elizabeth
Olsen, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Madison, WI USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Olsen, Christopher
Perdue, Michael L.
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h-index: 0
机构:
HHS, Washington, DC USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Perdue, Michael L.
Russell, Colin A.
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h-index: 0
机构:
Univ Cambridge, Dept Zool, Cambridge CB2 1TN, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Russell, Colin A.
Smith, Catherine
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机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Catherine
Smith, Derek
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h-index: 0
机构:
Univ Cambridge, Dept Zool, Cambridge CB2 1TN, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Derek
Smith, Gavin J. D.
论文数: 0引用数: 0
h-index: 0
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Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Gavin J. D.
Shu, Yuelong
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h-index: 0
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Chinese Ctr Dis Control & Prevent, Beijing, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Shu, Yuelong
Tashiro, Masato
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Tokyo, JapanCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Tashiro, Masato
Vijaykrishna, Dhanasekaran
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h-index: 0
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Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Vijaykrishna, Dhanasekaran
Webster, Robert
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Memphis, TN USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
机构:
Vet Labs Agcy, Addlestone, Surrey, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Brown, Ian H.
Capua, Ilaria
论文数: 0引用数: 0
h-index: 0
机构:
Inst Zooprofilatt Sperimentale Venezie, Padua, ItalyCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Capua, Ilaria
Cattoli, Giovanni
论文数: 0引用数: 0
h-index: 0
机构:
Inst Zooprofilatt Sperimentale Venezie, Padua, ItalyCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Cattoli, Giovanni
Chen, Hualan
论文数: 0引用数: 0
h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Chen, Hualan
Cox, Nancy
论文数: 0引用数: 0
h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Cox, Nancy
Davis, C. Todd
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h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Davis, C. Todd
Donis, Ruben O.
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h-index: 0
机构:
Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Donis, Ruben O.
Fouchier, Ron A. M.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, NL-3000 DR Rotterdam, NetherlandsCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Fouchier, Ron A. M.
Garten, Rebecca
论文数: 0引用数: 0
h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Garten, Rebecca
Guan, Yi
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h-index: 0
机构:
Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Guan, Yi
Hay, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Med Res, MRC, London NW7 1AA, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Hay, Alan
Kawaoka, Yoshihiro
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Madison, WI USA
Univ Tokyo, Inst Med Sci, Tokyo, JapanCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Kawaoka, Yoshihiro
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机构:
Mackenzie, John
McCauley, John
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Med Res, MRC, London NW7 1AA, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
McCauley, John
Mumford, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
WHO, GIP, EPR, Geneva, SwitzerlandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Mumford, Elizabeth
Olsen, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Univ Wisconsin, Madison, WI USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Olsen, Christopher
Perdue, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
HHS, Washington, DC USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Perdue, Michael L.
Russell, Colin A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Zool, Cambridge CB2 1TN, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Russell, Colin A.
Smith, Catherine
论文数: 0引用数: 0
h-index: 0
机构:Ctr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Catherine
Smith, Derek
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Dept Zool, Cambridge CB2 1TN, EnglandCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Derek
Smith, Gavin J. D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Smith, Gavin J. D.
Shu, Yuelong
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Ctr Dis Control & Prevent, Beijing, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Shu, Yuelong
Tashiro, Masato
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Infect Dis, Tokyo, JapanCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Tashiro, Masato
Vijaykrishna, Dhanasekaran
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Hong Kong, Hong Kong, Peoples R ChinaCtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA
Vijaykrishna, Dhanasekaran
Webster, Robert
论文数: 0引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Memphis, TN USACtr Dis Control & Prevent, Mol Virol & Vaccines Branch, Influenza Div, NCIRD, Atlanta, GA 30333 USA