The use of anion exchange resins for the synthesis of combinatorial libraries containing aryl and heteroaryl ethers

Quaternary ammonium exchange resins (Amberlite(R) IRA-900) were prepared that contained each a mixture often aryloxides and heteroaryloxides. The feasibility of generating combinatorial libraries containing aryl and heteroaryl ethers was demonstrated by reacting the resin's with a single electrophile (n-butyl bromide) to afford mixtures of ether products. The advantages of using quaternary ammonium exchange resins over solution phase chemistry to prepare this library ore discussed. Copyright (C) 1996 Elsevier Science Ltd