Effects of Berberine in the Gastrointestinal Tract - A Review of Actions and Therapeutic Implications

被引：126

作者：

Chen, Chunqiu ^{[1
]}

Yu, Zhen ^{[1
]}

Li, Yongyu ^{[2
]}

Fichna, Jakub ^{[3
]}

Storr, Martin ^{[4
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Gen Surg, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Inst Digest Dis, Dept Pathophysiol, Shanghai 200092, Peoples R China

[3] Med Univ Lodz, Dept Biochem, PL-92215 Lodz, Poland

[4] Univ Munich, Dept Med, Munich, Germany

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2014年 / 42卷 / 05期

基金：

美国国家科学基金会;

关键词：

Berberine; Gastrointestinal Disorders; Potential Therapeutics; Colon Cancer; Intracellular Pathways; GLUCAGON-LIKE PEPTIDE-1; COLON-CANCER CELLS; ACTIVATED PROTEIN-KINASE; INDUCED DIABETIC-RATS; KAPPA-B ACTIVATION; PPAR-GAMMA PATHWAY; TNF-ALPHA; IN-VITRO; STIMULATED MACROPHAGES; ESCHERICHIA-COLI;

D O I：

10.1142/S0192415X14500669

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins. Recent studies have shown that berberine and its derivatives have significant biological effects on gastrointestinal (GI) and other functions and may become therapeutics for the treatment of diarrhea, gastroenteritis, diabetes, hyperlipidemia, cardiovascular diseases and inflammatory conditions. This paper summarizes the current knowledge on the actions of berberine in the GI tract. Binding and target sites, activated intracellular pathways, as well as the absorption and metabolismof berberine are discussed. Effects that may be useful in future clinical treatment, like antidiarrheal, anti-inflammatory and antitumor effects are critically reviewed and potential clinical applications are presented in detail.

引用

页码：1053 / 1070

页数：18

共 80 条

[1]

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling [J].