The BIOGENES system for knowledge-based bioprocess control

The application of knowledge-based control systems in the area of biotechnological processes has become increasingly popular over the past decade. This paper will outline the structure of the advanced knowledge-based part of the BIOGENES(C) control system for the control of bioprocesses such as the fed-batch Saccharomyces cerevisiae cultivation. First, a brief overview of all the tasks implemented in the knowledge-based level including process data classification, qualitative process state identification and supervisory process control is given. The procedures performing the on-line identification of metabolic states and supervisory process control (setpoint calculation and control strategy selection) are described in more detail. Finally, the performance of the system is discussed using results obtained from a number of experimental cultivation runs in a laboratory unit. (C) 2002 Etsevier Science Ltd. All rights reserved.