Myocardial tissue engineering: Creating a muscle patch for a wounded heart

被引：50

作者：

Leor, J ^{[1
]}

Cohen, S

机构：

[1] Tel Aviv Univ, Chaim Sheba Med Ctr, Neufeld Cardiac Res Inst, IL-52621 Tel Hashomer, Israel

[2] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Inst Appl Biosci, IL-84105 Beer Sheva, Israel

来源：

CARDIAC ENGINEERING: FROM GENES AND CELLS TO STRUCTURE AND FUNCTION | 2004年 / 1015卷

关键词：

biomaterial; cell; heart; three-dimensional scaffold;

D O I：

10.1196/annals.1302.026

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problem of heart donor shortage. By its broad definition, tissue engineering involves the construction of tissue equivalents from donor cells seeded within three-dimensional polymeric scaffolds, then culturing and implanting of the cell-seeded scaffolds to induce and direct the growth of new, healthy tissue. Here, we present an up-to-date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles.

引用

页码：312 / 319

页数：8

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