Studies to determine the immunomodulating effects of cis-urocanic acid

被引：27

作者：

Norval, M ^{[1
]}

El-Ghorr, AA ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland

来源：

METHODS | 2002年 / 28卷 / 01期

关键词：

D O I：

10.1016/S1046-2023(02)00210-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure to ultraviolet (UV) radiation, particularly the UVB wavelengths, leads not only to DNA damage but also to suppression of cell-mediated immunity to antigens encountered shortly after the irradiation. One initiator of this complex process is cis-urocanic acid (cis-UCA), which is formed from the naturally occurring trans isomer in the epidermis on absorption of UV. cis-UCA has been shown to have immunomodulating properties in a variety of in vivo and in vitro experimental systems, although its mechanism of action is not yet clear. This article covers methods of preparing cis-UCA and of analyzing UCA isomers in various human and mouse tissues. Experiments that demonstrate that cis-UCA is immunosuppressive are described. The final section deals with the preparation and characterization of a monoclonal antibody with specificity for cis-UCA. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：63 / 70

页数：8

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