Inhibitory effects of natural sesquiterpenoids isolated from the rhizomes of Curcuma zedoaria on prostaglandin E2 and nitric oxide production

被引：39

作者：

Hong, CH ^{[1
]}

Noh, MS ^{[1
]}

Lee, WY ^{[1
]}

Lee, SK ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seodaemun Ku, Seoul 120750, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 06期

关键词：

D O I：

10.1055/s-2002-32560

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

beta-Turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglandin E-2 production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC50 = 7.3 muM for beta-turmerone; IC50 = 24.0 muM for ar-turmerone). In addition, these compounds exhibited inhibitory effects on LPS-induced nitric oxide production in the cell system.

引用

页码：545 / 547

页数：3

共 5 条

[1] Sesquiterpenoids from the rhizome of Curcuma zedoaria [J].

Hong, CH ;

Kim, Y ;

Lee, SK .

ARCHIVES OF PHARMACAL RESEARCH, 2001, 24 (05) :424-426

[2] Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships [J].

Kim, HK ;

Cheon, BS ;

Kim, YH ;

Kim, SY ;

Kim, HP .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (05) :759-765

[3] Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury [J].

Matsuda, H ;

Ninomiya, K ;

Morikawa, T ;

Yoshikawa, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (04) :339-344

[4] ENZYME IMMUNOASSAYS OF EICOSANDOIDS USING ACETYLCHOLINE ESTERASE AS LABEL - AN ALTERNATIVE TO RADIOIMMUNOASSAY [J].

PRADELLES, P ;

GRASSI, J ;

MACLOUF, J .

ANALYTICAL CHEMISTRY, 1985, 57 (07) :1170-1173

[5] Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene [J].

Yoshioka, T ;

Fujii, E ;

Endo, M ;

Wada, K ;

Tokunaga, Y ;

Shiba, N ;

Hohsho, H ;

Shibuya, H ;

Muraki, T .

INFLAMMATION RESEARCH, 1998, 47 (12) :476-481

← 1 →