Conjugated Polyelectrolyte Capsules: Light-Activated Antimicrobial Micro "Roach Motels"

被引：94

作者：

Corbitt, Thomas S. ^{[1
,2
]}

Sommer, Jonathan R. ^{[3
]}

Chemburu, Sireesha ^{[1
,2
]}

Ogawa, Katsu ^{[3
]}

Ista, Linnea K. ^{[1
,2
]}

Lopez, Gabriel P. ^{[1
,2
]}

Whitten, David G. ^{[1
,2
]}

Schanze, Kirk S. ^{[3
]}

机构：

[1] Univ New Mexico, Ctr Biomed Engn, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Dept Chem & Nucl Engn, Albuquerque, NM 87131 USA

[3] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ACS APPLIED MATERIALS & INTERFACES | 2009年 / 1卷 / 01期

关键词：

biocide; conjugated polymer; singles oxygen; polyelectrolyte capsule; confocal microscopy; GRAM-NEGATIVE BACTERIA; CARBONATE MICROPARTICLES; ANTIBACTERIAL SURFACES; BIOFILMS; PERMANENT; CONTACT;

D O I：

10.1021/am800096q

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Microcapsules consisting of alternating layers of oppositely charged poly(phenylene ethynylene)-type conjugated polyelectrolytes (CPEs) were prepared via layer-by-layer deposition onto MnCO3 template particles followed by dissolution of the template particles using an ethylenediaminetetraacetate solution. The resulting microcapsules exhibit bright-green fluorescence emission characteristics of the CPEs. Strong antimicrobial activity was observed upon mixing Of polyelectrolyte capsules with Cobetia marina or Pseudomonas aeruginosa followed by white-light irradiation. It was demonstrated that the materials act as highly effective light-activated micro "Roach Motels" with greater than 95% kill after exposure to similar to 1h of white light.

引用

页码：48 / 52

页数：5

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