Extractable polysaccharides of Panax quinquefolius L. (North American ginseng) root stimulate TNFα production by alveolar macrophages

被引：51

作者：

Assinewe, VA

Arnason, JT

Aubry, A

Mullin, J

Lemaire, I

机构：

[1] Univ Ottawa, Dept Cellular & Mol Med, Fac Med, Ottawa, ON K1H 8M5, Canada

[2] Univ Ottawa, Dept Biol, Ottawa, ON, Canada

[3] Agr & Agri Food Canada, Greenhouse & Proc Crops Res Ctr, Harrow, ON, Canada

来源：

PHYTOMEDICINE | 2002年 / 9卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Panax quinquefolius; North American ginseng; TNF alpha; ginsenosides; polysaccharides; macrophage activation;

D O I：

10.1078/09447110260571625

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We have investigated the immunostimulatory activity of the medicinal plant Panax quinquefolius L. (North American ginseng). Rat alveolar macrophages were treated with different extracts from 4-year old roots, and tumour necrosis factor alpha (TNF) production was used as a measure of immunostimulatory activity. Aqueous extracts of P. quinquefolius root (1-100 mug/ml) were found to significantly stimulate alveolar macrophage TNF release. Both a P. quinquefolius methanol extract containing ginsenosides (but no polysaccharides), and pure ginsenoside-Rb1, the major ginsenoside present in P. quinquefolius, were found to be inactive as TNF-stimulating agents. Significant TNF-stimulating activity was found in the extractable polysaccharide fraction, which was hydrolyzed and found to contain glucose, galactose, arabinose, rhamnose, and mannose. This represents the first evidence that North American ginseng exerts cytokine-stimulating activity on macrophages.

引用

页码：398 / 404

页数：7

共 32 条

[1] Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, ginseng radix: Possible roles of macrophages in the host defense mechanisms [J].