MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women

被引：27

作者：

Jaakelainen, Ester

Keski-Nisula, Leea

Toivonen, Sari

Romppanen, Eeva-Liisa

Helisaim, Seppo

Punnonen, Kari

Heinonen, Seppo ^{[1
]}

机构：

[1] Kuopio Univ Hosp, Dept Obstet & Gynecol, Kuopio 70211, Finland

[2] Univ Kuopio, Dept Obstet & Gynecol, FIN-70211 Kuopio, Finland

[3] Univ Kuopio, Dept Clin Chem, FIN-70211 Kuopio, Finland

[4] Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland

[5] Univ Kuopio, Dept Clin Genet, FIN-70211 Kuopio, Finland

来源：

HYPERTENSION IN PREGNANCY | 2006年 / 25卷 / 02期

关键词：

MTHFR; C677T; preeclampsia; placental abruption; Finnish;

D O I：

10.1080/10641950600745137

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia. Methods: 362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were genotyped for C677T polymorphism in the MTHFR gene. Results: Similar genotype distributions were observed in the frequencies of C/C homozygotes (58.6%, 64.1%, and 57.1% for the three groups, respectively) and mutant homozygotes T/T (9.0%, 5.1% and 5.4%). No significant differences were detected in T allele frequencies (25.2%, 20.5%, and 24.1% for the three groups, respectively). Conclusions: MTHFR C677T polymorphism does not have a major role in the development of preeclanipsia or placental abruption in the Finnish population.

引用

页码：73 / 80

页数：8

共 25 条

[1] Thrombophilias as risk factors for disorders of pregnancy and fetal damage [J].