Multiple sources of endogenous opioid peptide involved in the hypoglycemic response to 15 Hz electroacupuncture at the Zhongwan acupoint in rats

被引：35

作者：

Lin, JG

Chen, WC

Hsieh, CL

Tsai, CC

Cheng, YW

Cheng, JT

Chang, SL

机构：

[1] W China Univ Med Sci, Grad Inst Integrat Chinese & Western Med, Taichung, Taiwan

[2] W China Univ Med Sci, Grad Inst Chinese Med Sci, Taichung, Taiwan

[3] Taipei Chinese Med Assoc, Taipei, Taiwan

[4] W China Univ Med Sci, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan

[5] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan

来源：

NEUROSCIENCE LETTERS | 2004年 / 366卷 / 01期

关键词：

electroacupuncture; adrenalectomy; plasma glucose; beta-endorphin; insulin; opioid receptor knockout mice;

D O I：

10.1016/j.neulet.2004.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A decrease in plasma glucose levels was observed in rats which received electroacupuncture (EA) stimulation at the Zhongwan acupoint. In the present study, the role of the adrenal gland in this hypoglycemic response to EA at high frequency (15 Hz) was investigated on adrenalectomized (ADX) normal rats. There was a sharper decrease in plasma glucose by EA stimulation in the fasting ADX group than in the fasting sham-operated group. Naloxone blocked this hypoglycemic response to EA stimulation in rats which received ADX. Stimulation of EA failed to elicit an increase in plasma P-endorphin and insulin levels in ADX rats. Similar results were observed in sham and ADX mice. EA stimulation of ADX mice can reduce plasma glucose levels. Furthermore, naloxone abolished the hypoglycemic response to EA stimulation in mice. Such a hypoglycemic response to EA stimulation was also observed in mu-opioid receptor knockout mice (MOR-KOM). Mediation by another opioid peptide should also be considered in future experiments. We conclude that multiple sources of endogenous opioid peptide participated in the lowering of plasma glucose in rats induced by EA stimulation at higher frequency (15 Hz) at the Zhongwan acupoint. Increase in P-endorphin levels from the adrenal gland enhances the secretion of insulin, there by reducing plasma glucose levels, and is partially involved in this EA stimulation. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：39 / 42

页数：4

共 19 条

[1] Endogenous opioid peptides stimulate post-exercise insulin response to glucose in rats [J].