Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A2 and 5-lipoxygenase catalyzed pathway

被引：121

作者：

Taylor, PM ^{[1
]}

Woodfield, RJ ^{[1
]}

Hodgkin, MN ^{[1
]}

Pettitt, TR ^{[1
]}

Martin, A ^{[1
]}

Kerr, DJ ^{[1
]}

Wakelam, MJO ^{[1
]}

机构：

[1] Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England

来源：

ONCOGENE | 2002年 / 21卷 / 37期

基金：

英国惠康基金;

关键词：

EMMPRIN; MMP2; phospholipase A(2); 5-lipoxygenase; breast cancer cell; fibroblast;

D O I：

10.1038/sj.onc.1205702

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metalloproteinases (NIMP) produced by both cancer and normal stromal fibroblast cells play a critical role in the metastatic spread of tumours, however little is known of the regulation of their release. In this report we demonstrate that breast cancer cells in culture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibroblasts. The generation of MMP2 is mediated by activation of phospholipase A(2) and 5-lipoxygenase. These results suggest that the production of soluble EMMPRIN, phospholipase A(2) and 5-lipoxygenase activities are sites for potential therapeutic intervention.

引用

页码：5765 / 5772

页数：8

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