Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records

被引：243

作者：

Bell, Steven ^{[1
,2
]}

Daskalopoulou, Marina ^{[3
]}

Rapsomaniki, Eleni ^{[4
]}

George, Julie ^{[4
]}

Britton, Annie ^{[2
]}

Bobak, Martin ^{[2
]}

Casas, Juan P. ^{[4
]}

Dale, Caroline E. ^{[4
]}

Denaxas, Spiros ^{[4
]}

Shah, Anoop D. ^{[4
]}

Hemingway, Harry ^{[4
]}

机构：

[1] Univ Cambridge, Strangeways Res Lab, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[2] UCL, Res Dept Epidemiol & Publ Hlth, London WC1E 7HB, England

[3] UCL, Royal Free Hosp, Dept Infect & Populat Hlth, London NW3 2PF, England

[4] UCL, Farr Inst Hlth Informat Res London, London NW1 2DA, England

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2017年 / 356卷

基金：

英国工程与自然科学研究理事会; 英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院; 欧洲研究理事会; 英国经济与社会研究理事会;

关键词：

ISCHEMIC-HEART-DISEASE; DOSE-RESPONSE METAANALYSIS; SUDDEN CARDIAC DEATH; MYOCARDIAL-INFARCTION; RISK-FACTORS; MENDELIAN RANDOMIZATION; DRINKING PATTERNS; PHYSICAL-ACTIVITY; ANGINA-PECTORIS; LIFETIME RISKS;

D O I：

10.1136/bmj.j909

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES To investigate the association between alcohol consumption and cardiovascular disease at higher resolution by examining the initial lifetime presentation of 12 cardiac, cerebrovascular, abdominal, or peripheral vascular diseases among five categories of consumption. DESIGN Population based cohort study of linked electronic health records covering primary care, hospital admissions, and mortality in 1997-2010 (median follow-up six years). SETTING CALIBER (ClinicAl research using LInked Bespoke studies and Electronic health Records). PARTICIPANTS 1937360 adults (51% women), aged >= 30 who were free from cardiovascular disease at baseline. MAIN OUTCOME MEASURES 12 common symptomatic manifestations of cardiovascular disease, including chronic stable angina, unstable angina, acute myocardial infarction,

引用

页数：11

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