Spectroelectrochemical study of the interaction between antitumor drug daunomycin and DNA in the presence of antioxidants

被引：12

作者：

Cheng, GF ^{[1
]}

Qu, HY ^{[1
]}

Zhang, DM ^{[1
]}

Zhang, JD ^{[1
]}

He, PG ^{[1
]}

Fang, YZ ^{[1
]}

机构：

[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 29卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

DNA damage; spectroelectrochemistry; free radical; antioxidant; scavenger;

D O I：

10.1016/S0731-7085(02)00074-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Anthracycline drug daunomycin (DNR) is a widely used clinical drug. But its side effects, especially cardiotoxicity, have greatly restrained its application. The side effects were due to free radical formation in the metabolic process of DNR. The purpose of this study is to diminish the side effects by using antioxidants. Two kinds of free radical scavengers have been investigated, that is, vitamins: vitamin C (V-C), rutin (V-P) and vitamin B6 (V-B6); amino acids: cysteine (CysH) and methionine (Met). Free radical scavenging efficiency (Edegrees(eff)) of these antioxodants had been calculated. Under the experimental condition, the values of Edegrees(eff) of V-C, V-P, V-B6, CysH and Met were 23.8, 15.3, 6.4, 48.2 and -7.7%, respectively. The relationship between the free radical scavenging activities and its chemical structure has also been discussed. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：361 / 369

页数：9

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