Controlling the frontier: Regulatory T-cells and intestinal homeostasis

被引：84

作者：

Bollrath, Julia ^{[1
]}

Powrie, Fiona M. ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Div Expt Med,Translat Gastroenterol Unit, Oxford OX3 9DU, England

来源：

SEMINARS IN IMMUNOLOGY | 2013年 / 25卷 / 05期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Regulatory T-cells; Intestine; Microbiota; Inflammatory bowel disease; GROWTH-FACTOR-BETA; TOLL-LIKE RECEPTORS; TGF-BETA; WASTING DISEASE; FOXP3; GENE; INTERLEUKIN-10; INDUCTION; COMMENSAL; TOLERANCE; COLITIS;

D O I：

10.1016/j.smim.2013.09.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The intestine represents one of the most challenging sites for the immune system as immune cells must be able to mount an efficient response to invading pathogens while tolerating the large number and diverse array of resident commensal bacteria. Foxp3(+) regulatory T-cells (Tregs) play a non-redundant role at maintaining this balance. At the same time Treg cell differentiation and function can be modulated by the intestinal microbiota. In this review, we will discuss effector mechanisms of Treg cells in the intestine and how these cells can be influenced by the intestinal microbiota. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：352 / 357

页数：6

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