Reversible neural inactivation reveals hippocampal participation in several memory processes

被引:401
作者
Riedel, G
Micheau, J
Lam, AGM
Roloff, EV
Martin, SJ
Bridge, H
de Hoz, L
Poeschel, B
McCulloch, J
Morris, RGM
机构
[1] Univ Edinburgh, Sch Med, Dept Neurosci, Edinburgh EH8 9LE, Midlothian, Scotland
[2] Univ Edinburgh, Sch Med, Ctr Neurosci, Edinburgh EH8 9LE, Midlothian, Scotland
[3] Univ Aberdeen, Dept Biomed Sci, Aberdeen AB25 2ZD, Scotland
[4] Univ Bordeaux 1, Lab Neurosci Comportementales & Cognit, CNRS, UMR 5807, F-33405 Talence, France
[5] Univ Glasgow, Wellcome Surg Inst, Dept Neurosci, Glasgow G61 1QH, Lanark, Scotland
基金
英国惠康基金;
关键词
D O I
10.1038/13202
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Studies of patients and animals with brain lesions have implicated the hippocampal formation in spatial, declarative/relational and episodic types of memory. These and other types of memory consist of a series of interdependent but potentially dissociable memory processes-encoding, storage, consolidation and retrieval. To identify whether hippocampal activity contributes to these processes independently, we used a novel method of inactivating synaptic transmission using a water-soluble antagonist of AM PA/kainate glutamate receptors. Once calibrated using electrophysiological and two-deoxyglucose techniques in vivo, drug or vehicle was infused chronically or acutely into the dorsal hippocampus of rats at appropriate times during or after training in a water maze. Our findings indicate that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.
引用
收藏
页码:898 / 905
页数:8
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