Expression of fosB mRNA in the hamster suprachiasmatic nucleus is induced at only selected circadian phases

被引:15
作者
Guido, ME
Rusak, B
Robertson, HA
机构
[1] DALHOUSIE UNIV,DEPT PSYCHOL,LIFE SCI CTR,HALIFAX,NS B3H 4J1,CANADA
[2] DALHOUSIE UNIV,DEPT PHARMACOL,HALIFAX,NS B3H 4J1,CANADA
基金
英国医学研究理事会;
关键词
suprachiasmatic nucleus; circadian rhythm; fosB; c-fos; gene expression; immediate-early gene; light; entrainment; transcription regulation;
D O I
10.1016/S0006-8993(96)00816-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have studied the expression of fosB mRNA in the suprachiasmatic nucleus (SCN) of hamsters by in situ hybridization using oligonucleotides with sequences complementary to the C-terminal of the fosB mRNA sequence. In animals exposed for 48 h to darkness, there was little or no background expression in SCN cells of fosB mRNA at any circadian phase. Light pulses (30 min) were able to induce fosB expression only during the subjective night. Transcripts or fosB increased rapidly to peak by the end of a 30-min Light pulse. Light-induced increases gradually declined in darkness, but levels sen still elevated for up to 150 min alter the Light pulse. Induction in response to a light pulse was largely restricted to the ventrolateral portion of the nucleus which receiver the heaviest retinal projection. The temporal and anatomical pattern of fosB mRNA expression in the hamster SCN therefore resembles that reported previously for other immediate-early genes, such as c-fos.
引用
收藏
页码:132 / 138
页数:7
相关论文
共 39 条
[1]   N-METHYL-D-ASPARTATE RECEPTORS ARE CRITICAL FOR MEDIATING THE EFFECTS OF GLUTAMATE ON INTRACELLULAR CALCIUM-CONCENTRATION AND IMMEDIATE-EARLY GENE-EXPRESSION IN CULTURED HIPPOCAMPAL-NEURONS [J].
BADING, H ;
SEGAL, MM ;
SUCHER, NJ ;
DUDEK, H ;
LIPTON, SA ;
GREENBERG, ME .
NEUROSCIENCE, 1995, 64 (03) :653-664
[2]   PHOTIC INDUCTION AND CIRCADIAN EXPRESSION OF FOS-LIKE PROTEIN - IMMUNOHISTOCHEMICAL STUDY IN THE RETINA AND SUPRACHIASMATIC NUCLEI OF HAMSTER [J].
CHAMBILLE, I ;
DOYLE, S ;
SERVIERE, J .
BRAIN RESEARCH, 1993, 612 (1-2) :138-150
[3]   SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].
CHOMCZYNSKI, P ;
SACCHI, N .
ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159
[4]  
COLWELL CS, 1993, J NEUROSCI, V13, P1454
[5]   GLUTAMATE RECEPTOR-DRIVEN ACTIVATION OF TRANSCRIPTION FACTORS IN PRIMARY NEURONAL CULTURES [J].
CONDORELLI, DF ;
ALBANI, PD ;
AMICO, C ;
LUKASIUK, K ;
KACZMAREK, L ;
GIUFFRIDASTELLA, AM .
NEUROCHEMICAL RESEARCH, 1994, 19 (04) :489-499
[6]   PRESENCE AND INDUCTION OF FOS B-LIKE IMMUNOREACTIVITY IN NEURAL, BUT NOT NONNEURAL, CELLS IN ADULT-RAT BRAIN [J].
DRAGUNOW, M .
BRAIN RESEARCH, 1990, 533 (02) :324-328
[7]  
EBLING FJP, 1994, ADV PINEAL, V8, P77
[8]   MAINTAINED DISCHARGE OF RAT SUPRACHIASMATIC NEURONS AT DIFFERENT ADAPTATION LEVELS [J].
GROOS, G ;
MASON, R .
NEUROSCIENCE LETTERS, 1978, 8 (01) :59-64
[9]  
GUIDO ME, 1995, SOC NEUR ABSTR, V21
[10]  
GUIDO ME, 1996, IN PRESS MOL BRAIN R