Perturbation of natural killer cell function and receptors during HIV infection

被引：23

作者：

Eger, KA ^{[1
]}

Unutmaz, D ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 07期

关键词：

D O I：

10.1016/j.tim.2004.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural killer (NK) cells play an important role in innate host defenses against a variety of pathogens. A recent report described striking perturbations in the expression of NK cell inhibitory and activating receptors in viremic human immunodeficiency virus (HIV)-infected patients, leading to functional abnormalities in these cells. This finding provides a mechanistic insight into NK cell dysfunction and its possible contribution to the impairment of innate host defenses in HIV-infected individuals.

引用

页码：301 / 303

页数：3

共 25 条

[1] Modulation of expression of the MHC class I-binding natural killer cell receptors, and NK activity in relation to viral load in HIV-infected/AIDS patients [J].

Ahmad, R ;

Sindhu, STAK ;

Tran, P ;

Toma, E ;

Morisset, R ;

Menezes, J ;

Ahmad, A .

JOURNAL OF MEDICAL VIROLOGY, 2001, 65 (03) :431-440

[2] Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes [J].

Bonaparte, MI ;

Barker, E .

AIDS, 2003, 17 (04) :487-494

[3] Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells [J].

Castriconi, R ;

Cantoni, C ;

Della Chiesa, M ;

Vitale, M ;

Marcenaro, E ;

Conte, R ;

Biassoni, R ;

Bottino, C ;

Moretta, L ;

Moretta, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4120-4125

[4] Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals [J].

Chun, TW ;

Justement, JS ;

Lempicki, RA ;

Yang, J ;

Dennis, G ;

Hallahan, CW ;

Sanford, C ;

Pandya, P ;

Liu, SY ;

McLaughlin, M ;

Ehler, LA ;

Moir, S ;

Fauci, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1908-1913

[5] The biology of human natural killer-cell subsets [J].

Cooper, MA ;

Fehniger, TA ;

Caligiuri, MA .

TRENDS IN IMMUNOLOGY, 2001, 22 (11) :633-640

[6] The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44) [J].

De Maria, A ;

Fogli, M ;

Costa, P ;

Murdaca, G ;

Puppo, F ;

Mavilio, D ;

Moretta, A ;

Moretta, L .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (09) :2410-2418

[7] What is going on with natural killer cells in HIV infection? [J].

Dines, I ;

Rumjanek, VM ;

Persechini, PM .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2004, 133 (04) :330-339

[8]

Fehniger TA, 1998, J IMMUNOL, V161, P6433

[9] Innate immunity in human immunodeficiency virus infection: Effect of viremia on natural killer cell function [J].

Kottilil, S ;

Chun, TW ;

Moir, S ;

Liu, SY ;

McLaughlin, M ;

Hallahan, CW ;

Maldarelli, F ;

Corey, L ;

Fauci, AS .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (07) :1038-1045

[10] NK cell receptors [J].

Lanier, LL .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :359-393

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