Computer-aided drug design: the role of quantitative structure-property, structure-activity and structure-metabolism relationships (QSPR, QSAR, QSMR)

被引：44

作者：

Buchwald, P

Bodor, N

机构：

[1] IVAX Res Inc, Miami, FL 33137 USA

[2] Univ Florida, Ctr Drug Discovery, Gainesville, FL USA

来源：

DRUGS OF THE FUTURE | 2002年 / 27卷 / 06期

关键词：

D O I：

10.1358/dof.2002.027.06.856934

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：577 / 588

页数：12

共 130 条

[1] Hydrogen bond structural group constants [J].

Abraham, MH ;

Platts, JA .

JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (10) :3484-3491

[2] When Pharma merges, R&D is the dowry [J].

Agnew, B .

SCIENCE, 2000, 287 (5460) :1952-1953

[3] Predicting the impact of physiological and biochemical processes on oral drug bioavailability [J].

Agoram, B ;

Woltosz, WS ;

Bolger, MB .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 50 :S41-S67

[4] Combinatorial informatics in the post-genomics era [J].

Agrafiotis, DK ;

Lobanov, VS ;

Salemme, FR .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (05) :337-346

[5] Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? [J].

Ajay ;

Walters, WP ;

Murcko, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) :3314-3324

[6] Predicting human oral bioavailability of a compound: Development of a novel quantitative structure-bioavailability relationship [J].

Andrews, CW ;

Bennett, L ;

Yu, LX .

PHARMACEUTICAL RESEARCH, 2000, 17 (06) :639-644

[7]

[Anonymous], MAGIC MOL DRUGS WORK

[8]

[Anonymous], 1970, BURGERS MED CHEM

[9]

[Anonymous], STRATEGY DRUG DESIGN

[10]

ARIENS EJ, 1971, DRUG DESIGN, V1

← 1 2 3 4 5 6 7 8 9 10 →