Pharmacogenetics - five decades of therapeutic lessons from genetic diversity

被引：239

作者：

Meyer, UA ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrg1428

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Physicians have long been aware of the subtle differences in the responses of patients to medication. The recognition that a part of this variation is inherited, and therefore predictable, created the field of pharmacogenetics fifty years ago. Knowing the gene variants that cause differences among patients has the potential to allow 'personalized' drug therapy and to avoid therapeutic failure and serious side effects.

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收藏

页码：669 / 676

页数：9

相关论文

共 63 条

[1] STEADY-STATE PLASMA LEVELS OF NORTRIPTYLINE INTWINS - INFLUENCE OF GENETIC FACTORS AND DRUG THERAPY [J].

ALEXANDERSON, B ;

EVANS, DAP ;

SJOQVIST, F .

BMJ-BRITISH MEDICAL JOURNAL, 1969, 4 (5686) :764-+

[2]

[Anonymous], MENDELS PRINCIPLES H

[3] EXTREMELY RAPID HYDROXYLATION OF DEBRISOQUINE - A CASE-REPORT WITH IMPLICATION FOR TREATMENT WITH NORTRIPTYLINE AND OTHER TRICYCLIC ANTIDEPRESSANTS [J].

BERTILSSON, L ;

ABERGWISTEDT, A ;

GUSTAFSSON, LL ;

NORDIN, C .

THERAPEUTIC DRUG MONITORING, 1985, 7 (04) :478-480

[4] MOLECULAR-BASIS FOR RATIONAL MEGAPRESCRIBING IN ULTRARAPID HYDROXYLATORS OF DEBRISOQUINE [J].

BERTILSSON, L ;

DAHL, ML ;

SJOQVIST, F ;

ABERGWISTEDT, A ;

HUMBLE, M ;

JOHANSSON, I ;

LUNDQVIST, E ;

INGELMANSUNDBERG, M .

LANCET, 1993, 341 (8836) :63-63

[5] MOLECULAR MECHANISM OF SLOW ACETYLATION OF DRUGS AND CARCINOGENS IN HUMANS [J].

BLUM, M ;

DEMIERRE, A ;

GRANT, DM ;

HEIM, M ;

MEYER, UA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5237-5241

[6]

BONICKE R, 1953, N-S ARCH EX PATH PH, V220, P321

[7]

BREWER GJ, 1971, AM J HUM GENET, V23, P92

[8] ENZYMATIC DEFICIENCY IN PRIMAQUINE-SENSITIVE ERYTHROCYTES [J].

CARSON, PE ;

FLANAGAN, CL ;

ICKES, CE ;

ALVING, AS .

SCIENCE, 1956, 124 (3220) :484-485

[9] Extension of a pilot study: Impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness [J].

Chou, WH ;

Yan, FX ;

de Leon, J ;

Barnhill, J ;

Rogers, T ;

Cronin, M ;

Pho, M ;

Xiao, V ;

Ryder, TB ;

Liu, WW ;

Teiling, C ;

Wedlund, PJ .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2000, 20 (02) :246-251

[10] STATUS OF PRIMAQUINE .3. TOXICITY OF PRIMAQUINE IN CAUCASIANS [J].

CLAYMAN, CB ;

ARNOLD, J ;

HOCKWALD, RS ;

YOUNT, EH ;

EDGCOMB, JH ;

ALVING, AS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1952, 149 (17) :1563-1568

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