Clinical significance of p16INK4A and p53 overexpression in endocrine tumors of the gastrointestinal tract

被引：12

作者：

Li, Anna Fen-Yau

Tsay, Shyh-Haw

Liang, Wen-Yih

Li, Wing-Yin

Chen, Jeou-Yuan

机构：

[1] Taipei Vet Gen Hosp, Dept Pathol, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2006年 / 126卷 / 06期

关键词：

neuroendocrine tumors; gastrointestinal tract; p16; p53; CD117;

D O I：

10.1309/5X6WBYJ3U94EEKNN

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This study was designed to determine the expression of p16, p53, and CD117 in gastrointestinal tract endocrine tumors. Immunohistochemical studies of p16, p53, and CD117 were performed in 57 gastrointestinal tract endocrine tumors, including 22 poorly differentiated endocrine carcinomas (PDECs) and 35 well-differentiated endocrine tumors (WDETs). Overexpression of p16 and p53 was observed in 16 (73%) and 10 (45%) of the PDECs, respectively, whereas only 1 WDET showed overexpression of p53 and none showed overexpression of p16. A total of 18 (82%) of the PDECs showed overexpression of p16 or p53 proteins. This is closely associated with PDEC (P <.0001). By using overexpression of p16 or p53 as the criteria for PDEC, the sensitivity and specificity are 81.8% and 97.1%, respectively, with positive and negative predictive values of 94.7% and 89.5%, respectively. CD117 was not detected in any of the 57 gastrointestinal endocrine tumors by immunohistochemical analysis.

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页码：856 / 865

页数：10

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