Adipocyte metabolism and obesity

被引：152

作者：

Attie, Alan D. ^{[1
]}

Scherer, Philipp E. ^{[2
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

adiponectin; leptin; inflammation; ADIPOSE-TISSUE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; GENE-EXPRESSION; KINASE-ACTIVITY; INFLAMMATION; HYPOXIA; ACCUMULATION; CONTRIBUTES; INHIBITION;

D O I：

10.1194/jlr.R800057-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review how fuel partitioning between adipocytes and other tissues affects insulin signaling pathways. We discuss the role of adipose tissue inflammation in adipocyte metabolism and whole-body insulin sensitivity. Finally, we mention the role of adipokines in autocrine and paracrine signaling.-Attie, A. D. and P. E. Scherer. Adipocyte metabolism and obesity. J. Lipid Res. 2009. S395-S399.

引用

收藏

页码：S395 / S399

页数：5

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