Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

被引：34

作者：

Barraja, Paola ^{[1
]}

Spano, Virginia ^{[1
]}

Diana, Patrizia ^{[1
]}

Carbone, Anna ^{[1
]}

Cirrincione, Girolamo ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Farmacochim Tossicol & Biol, I-90123 Palermo, Italy

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 38期

关键词：

Pyrrolo[3,4-h]quinazolines; Antiproliferative activity; Isoindole building blocks; Pyrimidine annelation; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; POTENT;

D O I：

10.1016/j.tetlet.2009.07.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of the pyrrolo[3,4-h]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46-18.4 mu M). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5389 / 5391

页数：3

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