Importance of Vitamin D and Calcium at Older Age

被引:26
作者
Bischoff-Ferrari, Heike A. [1 ,2 ,3 ]
Staehelin, Hannes B. [4 ]
机构
[1] Univ Zurich Hosp, Ctr Aging & Mobil, CH-8091 Zurich, Switzerland
[2] Univ Zurich Hosp, Rheumatol Clin, CH-8091 Zurich, Switzerland
[3] Univ Zurich Hosp, Inst Med Phys, CH-8091 Zurich, Switzerland
[4] Univ Basel Hosp, Geriatr Univ Clin, CH-4031 Basel, Switzerland
关键词
Vitamin D supplementation; prevention of falls of elderly; effects of vitamin D on muscle and bone health; safety of high vitamin D dosages; calcium supplementation and bone fractures;
D O I
10.1024/0300-9831.78.6.286
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
We review the potential of vitamin D for the prevention of falls and fractures. Evidence from randomized-controlled trials will be reviewed for both endpoints, as well as epidemiologic data that correlates higher 25-hydroxyvitamin D status with better bone and muscle health. This review summarizes the compelling dual benefit of vitamin D on bone and muscle health, a concept that is unique and important for optimal fracture prevention at higher age. We will review sources of vitamin D and calcium and also outline why calcium supplementation alone may not contribute to fracture prevention at higher age. This review concludes that vitamin D at a dose of at least 800 IU per day should be provided to all postmenopausal women and everybody starting at age 60 for optimal bone and muscle health. In combination with a vitamin D supplement, dairy products may be an optimal source of calcium at higher age as milk provides both calcium and protein
引用
收藏
页码:286 / 292
页数:7
相关论文
共 51 条
[1]
[Anonymous], J CLIN ENDOCRINOL ME
[2]
Vitamin D2 is much less effective than vitamin D3 in humans [J].
Armas, LAG ;
Hollis, BW ;
Heaney, RP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (11) :5387-5391
[3]
Vitamin D and its major metabolites: Serum levels after graded oral dosing in healthy men [J].
Barger-Lux, MJ ;
Heaney, RP ;
Dowell, S ;
Chen, TC ;
Holick, MF .
OSTEOPOROSIS INTERNATIONAL, 1998, 8 (03) :222-230
[4]
Effects of vitamin D and calcium supplementation on falls:: A randomized controlled trial [J].
Bischoff, HA ;
Stähelin, HB ;
Dick, W ;
Akos, R ;
Knecht, M ;
Salis, C ;
Nebiker, M ;
Theiler, R ;
Pfeifer, M ;
Begerow, B ;
Lew, RA ;
Conzelmann, M .
JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (02) :343-351
[5]
Positive association between 25-hydroxy, vitamin D levels and bone mineral density: A population-based study of younger and older adults [J].
Bischoff-Ferrari, HA ;
Dietrich, T ;
Orav, EJ ;
Dawson-Hughes, B .
AMERICAN JOURNAL OF MEDICINE, 2004, 116 (09) :634-639
[6]
Bischoff-Ferrari HA, 2006, ARCH INTERN MED, V166, P424
[7]
Bischoff-Ferrari HA, 2004, AM J CLIN NUTR, V80, P752
[8]
Effect of vitamin D on falls - A meta-analysis [J].
Bischoff-Ferrari, HA ;
Dawson-Hughes, B ;
Willett, WC ;
Staehelin, HB ;
Bazemore, MG ;
Zee, RY ;
Wong, JB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (16) :1999-2006
[9]
Fracture prevention with vitamin D supplementation - A meta-analysis of randomized controlled trials [J].
Bischoff-Ferrari, HA ;
Willett, WC ;
Wong, JB ;
Giovannucci, E ;
Dietrich, T ;
Dawson-Hughes, B .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (18) :2257-2264
[10]
Vitamin D receptor expression in human muscle tissue decreases with age [J].
Bischoff-Ferrari, HA ;
Borchers, M ;
Gudat, F ;
Dürmüller, U ;
Stähelin, HB ;
Dick, W .
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (02) :265-269