Regulation and function of the p53-related proteins: same family, different rules

被引：103

作者：

Lohrum, MAE ^{[1
]}

Vousden, KH ^{[1
]}

机构：

[1] NCI, Regulat Cell Growth Lab, FCRDC, Frederick, MD 21702 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(00)01736-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumour-suppressor protein p53 has recently been shown to belong to a family that includes two structurally related proteins, p63 and p73. Although all three proteins share similar transcriptional functions and the ability to induce apoptosis, each of them appears to play a distinct role in development and tumour suppression, In order for cell division to occur, the antiproliferative activities of these proteins must be tightly controlled, and exciting advances have been mane in our understanding of the pathways involved in regulating p53 activity.

引用

页码：197 / 202

页数：6

共 60 条

[1] Stabilization of wild-type p53 by hypoxia-inducible factor 1α [J].

An, WG ;

Kanekal, M ;

Simon, MC ;

Maltepe, E ;

Blagosklonny, MV ;

Neckers, LM .

NATURE, 1998, 392 (6674) :405-408

[2] Regulation of p53 stability [J].

Ashcroft, M ;

Vousden, KH .

ONCOGENE, 1999, 18 (53) :7637-7643

[3] The role of p53 in tumour suppression: lessons from mouse models [J].

Attardi, LD ;

Jacks, T .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) :48-63

[4] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[5] Mechanisms of p53-mediated apoptosis [J].

Bates, S ;

Vousden, KH .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (01) :28-37

[6] Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome [J].

Celli, J ;

Duijf, P ;

Hamel, BCJ ;

Bamshad, M ;

Kramer, B ;

Smits, APT ;

Newbury-Ecob, R ;

Hennekam, RCM ;

Van Buggenhout, G ;

van Haeringen, B ;

Woods, CG ;

van Essen, AJ ;

de Waal, R ;

Vriend, G ;

Haber, DA ;

Yang, A ;

McKeon, F ;

Brunner, HG ;

van Bokhoven, H .

CELL, 1999, 99 (02) :143-153

[7] The p53 family: same response, different signals? [J].

Chen, XB .

MOLECULAR MEDICINE TODAY, 1999, 5 (09) :387-392

[8] Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain [J].

Chi, SW ;

Ayed, A ;

Arrowsmith, CH .

EMBO JOURNAL, 1999, 18 (16) :4438-4445

[9] Excess β-catenin promotes accumulation of transcriptionally active p53 [J].

Damalas, A ;

Ben-Ze'ev, A ;

Simcha, I ;

Shtutman, N ;

Leal, JFN ;

Zhurinsky, J ;

Geiger, B ;

Oren, M .

EMBO JOURNAL, 1999, 18 (11) :3054-3063

[10] p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53 [J].

Davison, TS ;

Vagner, C ;

Kaghad, M ;

Ayed, A ;

Caput, D ;

Arrowsmith, CH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18709-18714

← 1 2 3 4 5 6 →