Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications

被引：51

作者：

Hanefeld, Phillip

Westedt, Ullrich

Wombacher, Ralf

Kissel, Thomas

Schaper, Andreas

Wendorff, Joachim H.

Greiner, Andreas

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[2] Univ Marburg, Sci Ctr Mat Sci, D-35032 Marburg, Germany

[3] Univ Marburg, Inst Pharmaceut Technol & Biopharm, D-35037 Marburg, Germany

来源：

BIOMACROMOLECULES | 2006年 / 7卷 / 07期

关键词：

D O I：

10.1021/bm050642k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(p-xylylene) (PPX) was deposited by chemical vapor deposition (CVD) on stainless steel substrates. These PPX films were coated by solution casting of poly( lactide)-poly(ethylene oxide)-poly(lactide) triblock copolymers (PLA-PEO-PLA) loaded with C-14-labeled paclitaxel. Adhesion of PLA-PEO-PLA on PPX substrate coatings was measured using the blister test method. Excellent adhesion of the block copolymers on PPX substrates was found. Stress behavior and film integrity of PLA-PEO-PLA was compared to pure PLA on unexpanded and expanded stent bodies and was found to be superior for the block copolymers. The release of paclitaxel from the biodegradable coatings was studied under physiological conditions using the scintillation counter method. Burst release of paclitaxel was observed from PLA-PEO-PLA layers regardless of composition, but an increase in paclitaxal loading was observed with increasing content of PEO.

引用

页码：2086 / 2090

页数：5

共 22 条

[1]

[Anonymous], 1997, HDB BIODEGRADABLE PO

[2]

BRECHTHOLD K, 2001, MACROMOLECULES, V34, P8641

[3] APPLICATION OF THE BLISTER TEST TO THE STUDY OF POLYMER POLYMER ADHESION [J].