RNA Interference: From Basic Research to Therapeutic Applications

被引：264

作者：

Kurreck, Jens ^{[1
]}

机构：

[1] Univ Stuttgart, D-7000 Stuttgart, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 08期

关键词：

gene expression; molecular biology; RNA interference; RNA; LOCKED NUCLEIC-ACID; DOUBLE-STRANDED-RNA; INFLUENCES SIRNA EFFICACY; GENE-EXPRESSION; IN-VITRO; CHEMICAL-MODIFICATION; LENTIVIRAL VECTOR; MAMMALIAN-CELLS; TARGET ACCESSIBILITY; SYSTEMATIC ANALYSIS;

D O I：

10.1002/anie.200802092

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An efficient mechanism for the sequence-specific inhibition of gene expression is RNA interference. In this process, double-stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAi-based clinical trials as a new therapeutic option. © 2009 wiley-vch verlag gmbh & co. KGaA.

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收藏

页码：1378 / 1398

页数：21

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