Ubiquitin-dependent degradation of TGF-β-activated Smad2

被引：288

作者：

Lo, RS ^{[1
]}

Massagué, J ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/70258

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SMAD proteins are phosphorylated by transforming growth factor-beta (TGF-beta) receptors and translocate to the nucleus, where they control transcription. Here we investigate the fate of activated Smad2. We show that receptor-mediated activation leads to multi-ubiquitination and subsequent degradation of Smad2 by the proteasome. Ubiquitination of Smad2 is a consequence of its accumulation in the nucleus. If degradation is averted, the phosphorylated Smad2 remains in the nucleus in an active state. By targeting Smad2 for destruction, TGF-beta ensures the irreversible termination of its own signalling function.

引用

页码：472 / 478

页数：7

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