Reeve's synthesis of 2-imino-4-thiazolidinone from alkyl (aryl) trichloromethylcarbinol revisited, a three-component process from aldehyde, chloroform and thiourea

被引：54

作者：

Blanchet, J ^{[1
]}

Zhu, JP ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91128 Palaiseau, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 23期

关键词：

2-imino-4-thiazolidinones; multicomponent reaction; thiourea; trichloromethyl carbinol;

D O I：

10.1016/j.tetlet.2004.04.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2-imino-4-thiazolidinones from readily accessible alkyl (aryl) trichloromethylcarbinols and thioureas under mild conditions is reported. A one-pot three-component synthesis of the title compounds from aldehyde, chloroform and thiourea is also developed for the first time. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：4449 / 4452

页数：4

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