Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan

被引：28

作者：

Bulka, A ^{[1
]}

Wiesenfeld-Hallin, Z ^{[1
]}

Xu, XJ ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Div Med Lab Sci & Technol, SE-14186 Stockholm, Sweden

来源：

BRAIN RESEARCH | 2002年 / 942卷 / 1-2期

关键词：

antinociception; dextromethorphan; methadone; morphine; NMDA receptor; opioid;

D O I：

10.1016/S0006-8993(02)02701-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The antinociceptive effect of morphine and methadone was tested in two substrains of Sprague-Dawley (SD) rats, from B&K Universal, Sweden (BK) and Mollegard, Denmark, (DK). In both sub-strains of SD rats subcutaneous morphine or methadone produced dose-dependent antinociception on the hot plate test. However, the effect of the opioids was less in DK-SD than BK-SD rats, particularly for morphine as it failed to produce maximal antinociception even at high doses. Dextromethorphan, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, potentiated the antinociceptive effect of morphine and methadone in the DK-SD rats. The potentiation of morphine by dextromethorphan was significantly greater than its effect on methadone at equipotent doses. The results showed that there is a sub-strain difference for SD rats in the response to the antinociceptive effect of opioids, which may be due to greater NMDA receptor activity in DK-SD than in BK-SD rats. The higher efficacy of methadone may be derived from its proposed NMDA receptor blocking property and/or high intrinsic activity. (C) 2002 Published by Elsevier Science B.V.

引用

页码：95 / 100

页数：6

共 32 条

[1] Neuronal inhibitory effects of methadone are predominantly opioid receptor mediated in the rat spinal cord in vivo [J].