A stereodivergent asymmetric approach to difluorinated aldonic acids

被引：23

作者：

Audouard, C

Barsukov, I

Fawcett, J

Griffith, GA

Percy, JM

Pintat, S

Smith, CA

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] Univ Leicester, Biol NMR Ctr, Leicester LE1 9HN, Leics, England

[3] Evotech OAI, Abingdon OX14 4SD, Oxon, England

[4] GlaxoSmithKline Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 13期

关键词：

D O I：

10.1039/b405067c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A (bromodifluoromethyl)alkyne has been deployed in a stereoselective route to difluorinated aldonic acid analogues, in which a Sharpless asymmetric dihydroxylation reaction and diastereoisomer separation set the stage for phenyl group oxidation.

引用

页码：1526 / 1527

页数：2

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